Roxanna Baer is a graduate of the Rhode Island School of Design. Steven Heller, the legendary art director of the New York Times Book Review, gave Roxanna her first editorial illustration assignment. She has gone on to illustrate for a broad range of clients, including The New York Times Travel and Op/Ed Sections, Scholastic, babyGap, and Chronicle Books.

Roxanna illustrated the children's book  Hooray for Feet! written by Susan Pearson. School Library Journal  wrote that her "Bright, buoyant illustrations catch the exuberance of the rhymes." She also illustrated the book, Anything you can do I can do better, a girl's guide to guy stuff, published by Chronicle Books. Some of those illustrations were awarded entry into the American Illustration 26 directory.

Roxanna also illustrated, an award-winning website. it was featured in the Communication Arts Interactive Annual, Print, and How magazines. It also won the Boston Ad Club's Francis J. Hatch award. The website helped teens with cancer get helpful information on appearance, social, and nutritional issues. Her lively illustrations "provided the perfect backdrop to the original, thoughtful content (which included fashion, feeling good and fitting-in) that achieves the primary goal of making teens feel socially comfortable despite their difficult circumstances." (Communication Arts Interactive Annual 8)

In addition to illustration, Roxanna has contributed to the design of many top magazines including SELF, Lucky, Bon Appetit, Architectural Digest, Allure, and Women's Health.